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Zoloft may raise risk for major bleeding in patients taking blood thinners

November 12th, 2012

A new study has found that patients who take the blood thinner Warfarin along with an antidepressant such as Zoloft may be at an increased risk for major bleeding. Patients taking antidepressants in a class known as selective serotonin reuptake inhibitors (SSRIs) as well as warfarin were 60% more likely to suffer major hemorrhaging than patients on warfarin but no SSRI.

According to the study, the increased risks of bleeding were for SSRIs specifically, not all antidepressants. Zoloft and other SSRIs have come under increased scrutiny after studies have revealed risks of side effects among different types of patients.

Women who take Zoloft during pregnancy are at an increased risk of severe birth defects, including persistent pulmonary hypertension of the newborn, omphalocele,  coarctation of the aorta and other heart defects. A study published in the New England Journal of Medicine found that women who use the drug during pregnancy are twice as likely to give birth to a child with setpal defects and other congenital Zoloft birth defects.

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