A study found that patients who use St. John’s Wort to treat mild-to-medium depression could be at risk of side effects if they pair it with a selective serotonin reuptake inhibitor antidepressant (SSRI) such as Zoloft. St. John’s Wort has been shown to be effective in treating less severe cases of depression and anxiety.
The study revealed that it is not uncommon for depression patients to take multiple antidepressants at the same time, which researchers say is cause for concern. Antidepressants such as Zoloft have been documented to possess an increased risk of SSRI side effects.
Several studies have investigated the link between Zoloft birth defects and women who use the drug during pregnancy. The drug’s manufacturer, Pfizer, faces thousands of Zoloft birth defect lawsuits alleging that the antidepressant caused children to be born with heart defects, brain defects and other congenital birth defects.